Text Box: "Victor Babes" University of Medicine and Pharmacy of Timisoara

Center for Modeling Biological Systems and Data Analysis (Centrul de Modelare a Sistemelor Biologice si Analiza Datelor, CMSBAD) has been founded in 2005; it is certified as a Class C research center (license No. 98/2005) by the National Council for Scientific Research in Higher Education (Consiliul National al Cercetarii Stiintifice din Invatamantul Superior, CNCSIS).

The main objective of our research center is a multidisciplinary approach to biological processes, which involves analysing the functional mechanisms of certain phenomena observed in living systems, constructing models of these phenomena and developing predictive computer simulations.

Recent papers present some of our research topics:
p53; Computational modelling; Medical data mining;

The Center for Modeling Biological Systems and Data Analysis intends to join the European Consortium "Virtual Physiological Human", which has a broad research agenda in the time interval 2008 - 2013.


Director: Prof. Univ. Dr. Gheorghe I Mihalas,

Contact: Prof. Univ. Dr. Adrian Neagu

University of Medicine and Pharmacy of Timisoara
Department of Medical Informatics
P-ta E Murgu 2, 300041-Timisoara, Romania

Splaiul Tudor Vladimirescu 14, 300173 -Timisoara, Romania

To contact us:

Department of Biophysics and Medical Informatics, University of Medicine and Pharmacy, Piata Eftimie Murgu, nr. 3, 300041 Timiºoara, RomaniaTimisoara, CMSBADSpecific activator and repressor transcription factors which bind to specific regulator DNA sequences, play an important role in gene activity control. Interactions between genes coding such transcription factors should explain the different stable or sometimes oscillatory gene activities characteristic for different tissues. Starting with the model P53-MDM2 described into [Mihalas GI, Simon Z, Balea G, Popa E. Possible oscillatory behaviour in P53-MDM2 interaction computer simulation. J Biol Syst 2000;8(1):21–9] and the process described into [Kohn KW, Pommier Y. Molecular interaction map of P53 and MDM2 logic elements, which control the off–on switch of P53 in response to DNA damage. Biochem Biophys Res Commun 2005;331:816–27] we enveloped a new model of this interaction. Choosing the delay as a bifurcation parameter we study the direction and stability of the bifurcating periodic solutions. Some numerical examples are finally given for justifying the theoretical results.Noveanu L, Muntean C, Kigyosi A, Georgeta Mihalaº CMSBAD


Center for Modeling Biological Systems and Data Analysis

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